effect of subchronic administration of aqueous artemisia annua extract on a1-adrenoceptor agonist-induced contraction of isolated aorta in rat

نویسندگان

توراندخت بلوچ نژاد

tourandokht baluchnejad mojarad مهرداد روغنی

mehrdad roghani نیره زارع

naiereh zare

چکیده

artemisia species, growing in almost all the northern hemisphere, is used in folk medicine of some countries as a remedy for hypertension. since some cardiovascular disorders including hypertension are accompanied with altered responsiveness of vascular alpha-adrenergic receptors, the effect of aqueous artemisia annua extract (100 and 200 mg kg-1) on a1-adrenoceptor agonist-induced contraction of rat aorta was investigsted. after 4 weeks, the contraction and endothelium-dependent and -independent relaxation response of extract-treated rats were recorded. the results showed that the contractile response of aortic rings with endothelium to phenylephrine in extract-treated rats decreases (p<0.01-0.0001) and their endothelium-dependent relaxation response to acetylcholine increases (p<0.01-0.001) significantly in comparison with controls. endothelium-denuded aortic rings from extract-treated rats also showed a significant decrease (p<0.05) in contractile response, but there was no considerable difference in their endothelium-independent relaxation response to isosorbide dinitrate. these data suggest that the aqueous extract of artemisia annua could attenuate contractile response and enhance the endothelium-dependent relaxation response of aortic rings from normal rats

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Effect of Subchronic Administration of Aqueous Artemisia annua Extract on a1-Adrenoceptor Agonist-Induced Contraction of Isolated Aorta in Rat

Artemisia species, growing in almost all the northern hemisphere, is used in folk medicine of some countries as a remedy for hypertension. Since some cardiovascular disorders including hypertension are accompanied with altered responsiveness of vascular alpha-adrenergic receptors, the effect of aqueous Artemisia annua extract (100 and 200 mg kg-1) on a1-adrenoceptor agonist-induced contraction ...

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عنوان ژورنال:
iranian biomedical journal

جلد ۹، شماره ۲، صفحات ۵۷-۶۲

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